Role of endogenous serotonin in psychedelic-like effects of psilocybin in mice
The present findings reveal an inverse correlation between cortical 5-HT levels and the acute psychedelic-like effects of psilocybin. Consequently, the enhancement of serotonergic activity induced by prior antidepressant treatment may underlie interindividual variability in the acute response to psychedelics. Investigating these mechanisms in relation to the sustained therapeutic outcomes of psilocybin could contribute to optimizing the efficacy of psychedelic-based therapies.
Authors
- J. Javier Meana (ORCID: https://orcid.org/0000-0002-7913-6714)
- Jorge E. Ortega (ORCID: https://orcid.org/0000-0001-8188-874X)
- Ines Erkizia-Santamaría (ORCID: https://orcid.org/0000-0002-6163-4571)
- Nerea Martínez-Álvarez
- Leyre Salinas-Novoa
Institutions
- University of the Basque Country (ES)
- Instituto de Salud Carlos III (ES)
- BioCruces Health research Institute (ES)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
Publication Details
- Journal
- The International Journal of Neuropsychopharmacology
- Published
- 2025-05-25
- DOI
- https://doi.org/10.1093/ijnp/pyaf035
- Citations
- 6
- Primary Topic
- Psychedelics and Drug Studies
- Type
- article
- Field-Weighted Citation Impact
- 13.84
Funders
- State of New Jersey Department of Education
- Fundación Vital Fundazioa
- Eusko Jaurlaritza
- Ministerio de Ciencia e Innovación
- Instituto de Salud Carlos III
- European Regional Development Fund
- Agencia Estatal de Investigación