Sex-related differences and associated transcriptional signatures in the brain ventricular system and cerebrospinal fluid development in full-term neonates
Male neonates present larger volumes and faster growth of the right lateral ventricle, likely linked to corresponding CP volume and growth pattern. The downregulation of DERL2 and upregulation of MRPL48 may contribute to these sex-related variations in the CSF system, suggesting a molecular basis for sex-specific brain development.
Authors
- Chaowei Fu (ORCID: https://orcid.org/0000-0003-0966-8552)
- Chao Jin (ORCID: https://orcid.org/0000-0002-5761-341X)
- Yuying Feng (ORCID: https://orcid.org/0000-0002-0581-2476)
- Lidan Gu (ORCID: https://orcid.org/0000-0002-1618-6992)
- Huifang Zhao (ORCID: https://orcid.org/0009-0008-7617-461X)
- Yuxin Sun
Institutions
- Xi'an Medical University (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2025-05-25
- DOI
- https://doi.org/10.1186/s13293-025-00719-2
- Primary Topic
- Fetal and Pediatric Neurological Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China
- Natural Science Basic Research Program of Shaanxi Province