Programmed death-ligand 1 tumor proportion score in predicting the safety and efficacy of PD-1/PD-L1 antibody-based therapy in patients with advanced non-small cell lung cancer: A retrospective, multicenter, observational study
A positive PD-L1 TPS (≥1%) was associated with improved PFS and an increased risk of irAEs in a real-world setting. The onset of irAEs was associated with improved PFS and OS in patients with advanced NSCLC receiving PD-1/PD-L1-based therapy.
Authors
- Bin Ai (ORCID: https://orcid.org/0000-0001-7257-751X)
- Qingwei Meng
- Qing Zhou (ORCID: https://orcid.org/0000-0002-8721-1534)
- Mengzhao Wang
- Minjiang Chen (ORCID: https://orcid.org/0000-0002-4040-6115)
- Chengzhi Zhou (ORCID: https://orcid.org/0000-0003-0029-6879)
- Yuequan Shi
- Yangchun Gu (ORCID: https://orcid.org/0000-0003-3278-7285)
- Cuiying Zhang (ORCID: https://orcid.org/0000-0003-4926-4202)
- Yongjie Shui (ORCID: https://orcid.org/0000-0002-5786-7321)
- Jian Fang (ORCID: https://orcid.org/0000-0003-3697-4563)
- Haoran Zhang (ORCID: https://orcid.org/0000-0001-9792-7600)
- Jia Liu (ORCID: https://orcid.org/0000-0003-0490-5109)
- Dongming Zhang (ORCID: https://orcid.org/0000-0003-2016-8639)
- Jian Zhao (ORCID: https://orcid.org/0000-0002-8862-0591)
- Wei Zhong (ORCID: https://orcid.org/0000-0002-0637-3743)
- Siyuan Yu (ORCID: https://orcid.org/0000-0002-2550-8201)
- Anwen Liu (ORCID: https://orcid.org/0000-0003-4012-9717)
- Cuimin Ding
- Yan Xu (ORCID: https://orcid.org/0009-0009-1445-252X)
- Xiaoxing Gao
- Yan Wang (ORCID: https://orcid.org/0000-0002-1743-6383)
Institutions
- Hebei Medical University (CN)
- Nanchang University (CN)
- Harbin Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Peking Union Medical College Hospital (CN)
- Peking University Cancer Hospital (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
- Fourth Hospital of Hebei Medical University (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- Inner Mongolia People's Hospital (CN)
- Peking University Third Hospital (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Chinese Medical Journal
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1097/cm9.0000000000003620
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05