Mapping the hippocampal spatial proteomic signature in male and female mice of an early Alzheimer’s disease model
We show for the first-time specific sex-dependent synaptic-plasticity proteome changes in dorsal/ventral hippocampi that modulate GSK-3β activity. These findings provide new insight into the early amyloidosis pathogenesis in AD and offer valuable, unique proteomic phenotypes as potential biomarkers and targets for early diagnosis and therapy in both sexes.
Authors
- Juan D. Navarro‐López (ORCID: https://orcid.org/0000-0002-1877-7833)
- Ana Contreras (ORCID: https://orcid.org/0000-0002-2185-0851)
- Lydia Jiménez‐Díaz (ORCID: https://orcid.org/0000-0001-9121-0334)
- Souhail Djebari (ORCID: https://orcid.org/0000-0002-8044-6461)
- Raquel Jiménez‐Herrera (ORCID: https://orcid.org/0000-0002-8755-0392)
Institutions
- University of Castilla-La Mancha (ES)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2025-05-25
- DOI
- https://doi.org/10.1186/s13293-025-00697-5
- Citations
- 2
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- European Commission
- Universidad de Castilla-La Mancha
- Junta de Comunidades de Castilla-La Mancha
- European Regional Development Fund
- Agencia Estatal de Investigación