Navigating the role of E-Cadherin Gene in Gastric carcinoma

Gastric cancer (GC) ranks the fifth most common cancer globally. It is a profoundly aggressive neoplasm with a high mortality rate. E-cadherin encoded by the gene CDH is involved in the pathogenesis of different malignant tumors including gastric cancer. It is enrolled in the progression, invasion and spread of the tumor. The E-cadherin is crucial for epithelial cells adherent together and it's down regulation loosens this connection which facilitate the cellular movement and changing into the epithelial-mesenchymal transition(EMT), a fact predominant in GC. This review focuses on the structure of E-cadherin, its function and pathogenesis in the development of GC and it's correlation with different pathological factors involved in GC like Helicobacter pylori infection and the drug resistance of gastric malignancy.