Microbial metabolism mediates the deteriorative effects of sedentary behaviour on insulin resistance
Prolonged sedentary time leads to a depletion of Roseburia sp. CAG:471 and Firmicutes bacterium CAG:83, and suppresses arginine biosynthesis. Decreased L-citrulline and L-serine function as key microbial effectors mediating the adverse effect of sedentary time on insulin sensitivity. Targeting gut microbiota holds promise to combat insulin resistance induced by excessive sedentary time.
Authors
- Jingmeng Ju (ORCID: https://orcid.org/0000-0001-6734-7840)
- Min Xia (ORCID: https://orcid.org/0000-0001-5330-6466)
- Bingqi Ye (ORCID: https://orcid.org/0000-0002-2049-391X)
- Jialu Yang
- Ludi Liu
- Wanlan Chen
- Wanying Zhao (ORCID: https://orcid.org/0000-0002-6339-3927)
- Yan Liu (ORCID: https://orcid.org/0000-0001-6358-4056)
- Jiaqi Zhao (ORCID: https://orcid.org/0000-0002-3564-5090)
- Siqi Li (ORCID: https://orcid.org/0000-0003-0445-6585)
- Qi Zhang (ORCID: https://orcid.org/0000-0001-9916-8919)
- Yi Li (ORCID: https://orcid.org/0000-0002-4326-2276)
- Jialin He (ORCID: https://orcid.org/0000-0002-6135-2638)
Institutions
- Sun Yat-sen University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/ctm2.70348
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China