YAP1 promoter-associated noncoding RNA affects Ewing sarcoma cell tumorigenicity by regulating YAP1 expression
PncRNA_YAP1-1 counteracts the YAP1 oncogenic transcriptional program in Ewing sarcoma cells by interfering with YAP1-TEAD interaction and impairing YAP1 protein stability. These findings uncover a novel treatment option for Ewing sarcoma.
Authors
- Lidia Chellini (ORCID: https://orcid.org/0000-0002-0612-8609)
- Veronica Riccioni (ORCID: https://orcid.org/0000-0002-5903-6281)
- Maria Paola Paronetto (ORCID: https://orcid.org/0000-0001-5324-0903)
- Arianna Del Verme
Institutions
- Foro Italico University of Rome (IT)
- Fondazione Santa Lucia (IT)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-05-25
- DOI
- https://doi.org/10.1186/s11658-025-00736-4
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero della Salute
- Associazione Italiana per la Ricerca sul Cancro