Systemic Lupus Erythematosus and Psoriasis Overlap: A Case Series

Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disorder known for its diverse clinical manifestations and potential for overlap with other connective tissue diseases. While overlap syndromes involving conditions such as rheumatoid arthritis (RA) and Sjögren's syndrome (SS) are well established, the coexistence of SLE and psoriasis remains relatively rare and under-reported, despite their distinct immunopathological mechanisms. We present a case series of four female patients diagnosed with both SLE and psoriasis based on expert medical opinion along with supporting biochemical evidence, who experienced complex, relapsing-remitting disease courses. Each case demonstrated unique challenges related to diagnosis, overlapping cutaneous and joint symptoms, and therapeutic management. Overall, we have noted that the use of biological therapy in our patients was effective in terms of clinical remission of psoriasis while avoiding the risk of an SLE flare.