Structural and functional roles of domain <scp>III</scp> in <scp>Vip3Aa</scp> and <scp>Vip3Ca</scp>: implications for membrane perforation and insecticidal efficacy
Targeted disruption of hydrogen bonds between residues in domain III and residue Y19 enhances the membrane perforation and insecticidal efficacy of Vip3Aa and Vip3Ca, offering a novel engineering strategy for optimizing biopesticides. © 2025 Society of Chemical Industry.
Authors
- Xiaoyue Hou (ORCID: https://orcid.org/0000-0001-8175-7707)
- Jun Cai (ORCID: https://orcid.org/0000-0002-5194-3629)
- Jiannan Guo (ORCID: https://orcid.org/0000-0001-9713-9671)
- Lei Jiang (ORCID: https://orcid.org/0000-0001-9588-2015)
- Wen Zhang (ORCID: https://orcid.org/0000-0002-9352-6153)
- Jiang Xu (ORCID: https://orcid.org/0000-0001-8051-2222)
- Mengying Li (ORCID: https://orcid.org/0000-0002-4699-5010)
- Chunxia Yang (ORCID: https://orcid.org/0009-0000-8440-8481)
- Yaowei Fang (ORCID: https://orcid.org/0000-0002-8482-508X)
- Jinxuan Wang
- Chengjuan Mao
Institutions
- Nankai University (CN)
- Jiangsu Yanjiang Chemical Resources Development Research Institute (China) (CN)
- College of Marin (US)
Publication Details
- Journal
- Pest Management Science
- Published
- 2025-05-24
- DOI
- https://doi.org/10.1002/ps.8922
- Citations
- 1
- Primary Topic
- Insect Resistance and Genetics
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- Jiangsu Ocean University