THE SECRET OF C3 GLOMERULOPATHY IN A LUPUS PATIENT

PV296 / #329 Case Report Poster Topic: AS22 - SLE Heterogeneity Introduction Objective Nephrological abnormalities in a patient with SLE are not exclusive to lupus nephropathy, but can reveal unexpected causes, as is the case in our patient. Case Presentation With Investigation Method Patient followed for an SLE whose histopathological study of the renal biopsy puncture objective an isolated C3 glomerulopathy. Results A 48 years old man followed for articular and hematological systemic lupus since the age of 19 years, presented persistent proteinuria with hematuria and consumption of complement. The histopathology of renal biopsy puncture,was in favor of a C3 glomerulopathy with active lesions.The exploration of this entity found a low third component of complement(C3:0.8g/l)and a monoclonal component of the IgG Lambda type. Glomerular filtration rate was normal (80 ml/mn).The diagnosis of monoclonal gammopathy of renal significance is more likely. Conclusion The SLE is a provider of nephropathy but the slightest atypia should alarm the clinician and the anatomical pathologist in order to broaden their diagnostic horizons Literature Review [1.] Ahmad SB. Adv Chronic Kidney Dis 2020;27(2):104-10. [2.] Heiderscheit AK. Am J Med Genet 2022;190(3):344-57. Discussion Conclusion: The SLE is a provider of nephropathy but the slightest atypia should alarm the clinician and the anatomical pathologist in order to broaden their diagnostic horizons