COVID-19 AND POST COVID-19 AND THE EMERGENCE OF SLE AND EXACERBATIONS

O046a / #565 Topic: AS01 - Adaptive Immunity ABSTRACT CONCURRENT SESSION 08: RECENT ADVANCES IN LUPUS BIOMARKERS 23-05-2025 1:40 PM - 2:40 PM Background/Purpose Covid-19 virus is an autoimmune virus and more notorious than EBV. It induces autoimmune diseases by hyperstimulation combined with induction of autoimmune disease by molecular mimicry. There are many autoimmune conditions which have emerged following the COVID 19 infection. One of them is SLE. We will summarize the various publications discussing de novo eruption of SLE as well as induction of exacerbation. Methods We assume the possibility of an alternative course of COVID-19, which develops in genetically predisposed individuals with a stronger immune response, in which it predominantly affects the cells of the nervous system, possibly with the presence of an autoimmune component, which might have similarity with chronic fatigue syndrome or autoimmune dysautonomia. Results We will discuss all the autoimmune ramifications of the virus, the CFS / fibromyalgia / post Covid syndrome.[1-7] and their association with SLE. Conclusions The detection of novel autoantibodies to the autonomic nervous system receptors will explain the pathogenic mechanism of many of the new complaints. References : [1.] Shoenfeld Y. Clin Immunol 2020;214:108384. [2.] Cabral-Marques O. Nature Commun 2022;13:1220. [3.] Dotan A. Int J Infect Dis 2022;114:233-5. [4.] Jara LJ. Clin Rheumatol 2022;41:1603-9. [5.] Ehrenfeld M. Autoimmun Rev 2020;19:102597. [6.] Perricone C. Immunol Res 2020;68:213-24. [7.] Halpert G. Autoimmun Rev 2020;19:102695.