Ileal FXR Knockdown Ameliorates MASLD Progression in Rats via Modulating Bile Acid Metabolism Mediated by Gut Microbiota
These findings suggest that downregulation of ileal FXR ameliorates the progression of MASLD in rats by modulating BA metabolism mediated by the gut microbiota, indicating that ileal FXR might be a potential therapeutic target for the treatment of MASLD.
Authors
- Xiaobo Cai
- Jingyi Lu (ORCID: https://orcid.org/0000-0003-1105-4189)
- Hui Dong (ORCID: https://orcid.org/0000-0003-4771-0846)
- Qingqing Zhang (ORCID: https://orcid.org/0000-0003-4443-1331)
- Junjun Wang (ORCID: https://orcid.org/0000-0001-9427-3824)
- Yufei Yang
- Jiaqi Gao (ORCID: https://orcid.org/0000-0002-0376-3930)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai First People's Hospital (CN)
Publication Details
- Journal
- Journal of Gastroenterology and Hepatology
- Published
- 2025-05-24
- DOI
- https://doi.org/10.1111/jgh.17017
- Citations
- 1
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- National Natural Science Foundation of China