Increased mucosal and T-cell expression of 4-1BB and PD-1 are modulated by anti-TNFα treatment in Crohn’s disease
A dysbalanced mucosal proinflammatory co-stimulatory T cell receptor expression was present in active CD and modified by anti-TNFα treatment. However, anti-TNFα treatment did not normalize the expression of 4-1BB or PD-1 on peripheral T cells although a modest increased immunoregulatory capacity could be demonstrated.
Authors
- Bent Deleuran (ORCID: https://orcid.org/0000-0002-7079-1587)
- Morten Aagaard Nielsen (ORCID: https://orcid.org/0000-0003-1077-9727)
- Line S. Reinert (ORCID: https://orcid.org/0000-0002-8317-0886)
- Christian Lodberg Hvas (ORCID: https://orcid.org/0000-0001-7973-7184)
- Jørgen Agnholt (ORCID: https://orcid.org/0000-0003-2822-6442)
- Mia Bendix (ORCID: https://orcid.org/0000-0002-6468-729X)
- Anders Dige (ORCID: https://orcid.org/0000-0001-9995-0329)
Institutions
- Aarhus University (DK)
- Aarhus University Hospital (DK)
- Regional Hospital Randers (DK)
Publication Details
- Journal
- Scandinavian Journal of Gastroenterology
- Published
- 2025-05-24
- DOI
- https://doi.org/10.1080/00365521.2025.2505622
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00