Low Expression Levels of Sodium Channels in the Right Ventricular Outflow Tract Underly the Genesis of the Characteristic Electrocardiogram Waveform in Brugada Syndrome

Strong selective inhibition of the sodium current in the right ventricular outflow tract generates the characteristic BrS-type ECG in the precordial leads without affecting the waveforms in other lead positions. This change can only be achieved using the embryonic phenotype model in which reduced expression levels of sodium channels play an essential role.