Gamma-glutamyltransferase testing in paediatric inflammatory bowel disease to screen for primary sclerosing cholangitis: a diagnostic study based on routinely collected electronic healthcare data

In children with IBD who have GGT elevations less than 2× ULN, the likelihood of PSC is extremely low. In such cases, MRCP and liver biopsy can be omitted. Regular GGT monitoring is advised, as PSC may develop over time.

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Publication Details

Journal
Archives of Disease in Childhood
Published
2025-05-24
DOI
https://doi.org/10.1136/archdischild-2024-327998
Primary Topic
Liver Diseases and Immunity
Type
article
Field-Weighted Citation Impact
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article

Gamma-glutamyltransferase testing in paediatric inflammatory bowel disease to screen for primary sclerosing cholangitis: a diagnostic study based on routinely collected electronic healthcare data

Besrat Berhane, Put W, Patrick F. van Rheenen
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Archives of Disease in Childhood
Liver Diseases and Immunity
article

Gamma-glutamyltransferase testing in paediatric inflammatory bowel disease to screen for primary sclerosing cholangitis: a diagnostic study based on routinely collected electronic healthcare data

Besrat Berhane, Put W, Patrick F. van Rheenen
article en

Abstract

In children with IBD who have GGT elevations less than 2× ULN, the likelihood of PSC is extremely low. In such cases, MRCP and liver biopsy can be omitted. Regular GGT monitoring is advised, as PSC may develop over time.

Archives of Disease in ChildhoodVol. 110(10)
University Medical Center Groningen (NL), University of Groningen (NL), Beatrix Kinderziekenhuis (NL)
Good health and well-being
Openalex Percentile: Top 83%
Liver Diseases and Immunity
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