Tocilizumab effectiveness in paediatric non-infectious uveitis: data from the International AIDA Network Registries on ocular inflammatory disorders
To describe tocilizumab (TCZ) effectiveness in 15 children with refractory non-infectious uveitis. Reported outcomes are the number of relapses before and after treatment, steroid-sparing effect and drug retention rate. Macular oedema, fluorangiographic findings and ocular complications are also reported.The mean number of ocular relapses significantly decreased from 314 per 100 eyes/year to 106 per 100 eyes/year (p=0.016). A significant steroid-sparing effect was detected (p=0.037). TCZ drug survival was 77.4% at 6 months, followed by 61.9% at 12, 24 and 36 months of follow-up. Macular oedema and retinal vasculitis resolved in all affected eyes.
Authors
- Bruno Frediani (ORCID: https://orcid.org/0000-0002-9375-5984)
- Maria Pia Paroli (ORCID: https://orcid.org/0000-0002-4395-4774)
- Francesca Minoia (ORCID: https://orcid.org/0000-0002-5093-8422)
- Emanuela Del Giudice (ORCID: https://orcid.org/0000-0002-3334-4884)
- Antonio Vitale (ORCID: https://orcid.org/0000-0003-4469-7332)
- Abdurrahman Tufan (ORCID: https://orcid.org/0000-0001-6244-9362)
- Edoardo Biancalana (ORCID: https://orcid.org/0000-0002-1410-4375)
- Silvana Guerriero (ORCID: https://orcid.org/0000-0002-6545-2273)
- Luca Cantarini (ORCID: https://orcid.org/0000-0002-7352-1275)
- Soad Hashad (ORCID: https://orcid.org/0000-0003-0500-7458)
- Alejandra de‐la‐Torre (ORCID: https://orcid.org/0000-0003-0684-1989)
- Saverio La Bella (ORCID: https://orcid.org/0000-0002-1244-0789)
- Jurgen Sota (ORCID: https://orcid.org/0000-0002-7549-2922)
- Claudia Fabiani (ORCID: https://orcid.org/0000-0003-4515-7741)
- Sulaiman M. Al‐Mayouf (ORCID: https://orcid.org/0000-0003-0142-6698)
- Luciana Breda (ORCID: https://orcid.org/0000-0002-1088-524X)
- Juanita Cardona-López (ORCID: https://orcid.org/0009-0004-3888-3870)
- María José Altamar-García
Institutions
- Alfaisal University (SA)
- University of Tripoli (LY)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- University of Chieti-Pescara (IT)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Azienda Ospedaliera Universitaria Senese (IT)
- University of Bari Aldo Moro (IT)
- Sapienza University of Rome (IT)
- Universidad del Rosario (CO)
- Gazi University (TR)
Publication Details
- Journal
- British Journal of Ophthalmology
- Published
- 2025-05-24
- DOI
- https://doi.org/10.1136/bjo-2025-327410
- Citations
- 4
- Primary Topic
- Ocular Diseases and Behçet’s Syndrome
- Type
- article
- Field-Weighted Citation Impact
- 6.83