Exosomal miR-1246 of adipose stem cells attenuates obesity by polarizing M2 macrophages, reducing fat mass, and beiging of white adipose tissue
Our study elucidates a novel molecular mechanism through which ADSC regulates adipose tissue homeostasis and metabolism and presents a potential therapeutic approach for treating obesity and related metabolic disorders via iADSC-EXO or miR-1246-based interventions.
Authors
- Huiming Xu (ORCID: https://orcid.org/0000-0003-4823-6920)
- Wei‐Qiang Gao (ORCID: https://orcid.org/0000-0002-0959-2570)
- Meijin Guo
- Bo Wang (ORCID: https://orcid.org/0000-0001-6898-9757)
- Mohsin Ali (ORCID: https://orcid.org/0000-0002-5409-7368)
- Qingmeng Pi
Institutions
- East China University of Science and Technology (CN)
- Renji Hospital (CN)
- State Key Laboratory of Oncogene and Related Genes (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-05-24
- DOI
- https://doi.org/10.1016/j.jare.2025.05.049
- Citations
- 3
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.42