Adoptively transferred macrophages for cancer immunotherapy
Owing to their inherent ability to home to and infiltrate inflamed tissues, macrophage-based cancer immunotherapies exhibited a unique in vivo trafficking behavior, efficiently reaching and persisting within tumors. Macrophages orchestrated a multiarmed immune attack led by CD8+T cells, with the potential for local, intratumoral activation of effector cells, demonstrating a novel cancer immunotherapy platform with meaningfully different characteristics than clinically evaluated alternatives.
Authors
- Kyong Soo Park (ORCID: https://orcid.org/0000-0003-3597-342X)
- Vineeth Chandran Suja (ORCID: https://orcid.org/0000-0002-3406-7655)
- Supriya Prakash (ORCID: https://orcid.org/0000-0003-0772-8822)
- Morgan E. Janes
- Neha Kapate (ORCID: https://orcid.org/0000-0003-4576-0014)
- Alexander P. Gottlieb (ORCID: https://orcid.org/0000-0003-2691-927X)
- Samir Mitragotri (ORCID: https://orcid.org/0000-0002-2459-8305)
- Liwen Wang (ORCID: https://orcid.org/0000-0002-0297-9553)
- Jennifer L. Guerriero (ORCID: https://orcid.org/0000-0002-2104-5457)
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Harvard–MIT Division of Health Sciences and Technology (US)
- Dana-Farber/Harvard Cancer Center (US)
- Dana-Farber Brigham Cancer Center (US)
- Massachusetts Institute of Technology (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1136/jitc-2024-010437
- Citations
- 3
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 2.39