Tailoring thresholds for interpreting plasma p-tau217 levels
Plasma p-tau217 demonstrated robust diagnostic accuracy across CI subgroups and highlighted the importance of tailored cut-off thresholds for CU populations. These findings support the integration of plasma p-tau217 into clinical workflows for AD diagnostics, emphasising its potential for early detection and risk stratification.
Authors
- Jun Pyo Kim
- Duk Lyul Na (ORCID: https://orcid.org/0000-0002-0098-7592)
- Jihwan Yun
- Fernando González‐Ortiz (ORCID: https://orcid.org/0000-0001-7897-9456)
- Seongmi Kim (ORCID: https://orcid.org/0009-0004-3144-9908)
- Soyeon Yoon
- Hyemin Jang (ORCID: https://orcid.org/0000-0003-3152-1274)
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Eun Hye Lee (ORCID: https://orcid.org/0000-0002-4206-6214)
- Sung Hoon Kang (ORCID: https://orcid.org/0000-0002-2481-0302)
- Hyun‐Sik Kang (ORCID: https://orcid.org/0000-0002-8611-1873)
- Kyoungmin Kim (ORCID: https://orcid.org/0009-0000-4161-3573)
- Hee Jin Kim (ORCID: https://orcid.org/0000-0003-1554-2657)
- Heejin Yoo (ORCID: https://orcid.org/0000-0003-4341-6906)
- Kyung‐A Kim (ORCID: https://orcid.org/0000-0002-2577-1317)
- Sang Won Seo (ORCID: https://orcid.org/0000-0003-2568-0797)
- Daeun Shin (ORCID: https://orcid.org/0000-0003-4834-1026)
- Nicholas J. Ashton
- Jin Seok Ahn
- Kaj Blennow
- S.F. Yim (ORCID: https://orcid.org/0000-0002-9357-768X)
Institutions
- King's College London (GB)
- Samsung (South Korea) (KR)
- Korea University Medical Center (KR)
- Sahlgrenska University Hospital (SE)
- Samsung Medical Center (KR)
- Seoul National University Hospital (KR)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Bucheon University (KR)
- Sungkyunkwan University (KR)
- University of Gothenburg (SE)
Publication Details
- Journal
- Journal of Neurology Neurosurgery & Psychiatry
- Published
- 2025-05-24
- DOI
- https://doi.org/10.1136/jnnp-2025-335830
- Citations
- 9
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 13.24
Funders
- Alzheimer's Association
- Korea Dementia Research Center
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Vetenskapsrådet
- Ministry of Science and ICT, South Korea
- UK Dementia Research Institute
- Korea National Institute of Health