Predicting the molecular mechanism of ginger targeting PRMT1/BTG2 axis to inhibit gastric cancer based on WGCNA and machine algorithms
In this study, we found that PRMT1 could be used as a biomarker for ginger against GC using network pharmacology, WGCNA and machine algorithms. We hypothesized that ginger may exert antitumor effects through PRMT1/BTG2, providing new insights into the pharmacological mechanism of ginger against GC.
Authors
- Ling Yuan (ORCID: https://orcid.org/0000-0001-7351-5097)
- Ziying Zhou
- Guoqing Chen (ORCID: https://orcid.org/0000-0002-3671-5257)
- Yuting Bai (ORCID: https://orcid.org/0000-0001-6079-1340)
- Yi Yang (ORCID: https://orcid.org/0000-0002-8466-5717)
- Yi Nan (ORCID: https://orcid.org/0000-0002-5511-9266)
- Yuhua Du (ORCID: https://orcid.org/0009-0006-6276-6062)
- Boyun Gou
Institutions
- Ningxia University (CN)
- Ningxia Medical University (CN)
- Ningxia Medical University General Hospital (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-05-24
- DOI
- https://doi.org/10.1016/j.phymed.2025.156892
- Citations
- 18
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 14.51