CCNA2 and CCND2 Are Differentially Involved in β-Cell Proliferation in Perinatal Japanese Autopsied Individuals
Our results provide the first morphological changes during islet cell development in Japanese autopsy samples, ranging from fetuses to adolescents, and show that CCNA2, assisted by CCND2, may play a central role in β-cell proliferation. Furthermore, CCND2-antisense 1 positively regulates cyclin D2 expression in pancreatic islets of during development. These results could be applied to future β-cell proliferation therapies.
Authors
- Yukihiro Fujita (ORCID: https://orcid.org/0000-0003-3238-8743)
- Sho Osonoi (ORCID: https://orcid.org/0000-0003-3018-5862)
- Kiminori Terui (ORCID: https://orcid.org/0000-0003-1294-8635)
- Takefusa Tarusawa
- Yi Tu (ORCID: https://orcid.org/0000-0002-2051-8806)
- Hiroki Mizukami (ORCID: https://orcid.org/0000-0003-2920-582X)
- Eiichi Ishiyama
- Takanori Sasaki (ORCID: https://orcid.org/0000-0002-2235-581X)
- Zhenchao Wang (ORCID: https://orcid.org/0000-0003-1859-0128)
- Hanae Kushibiki
- Soroku Yagihashi (ORCID: https://orcid.org/0000-0003-4255-774X)
- Kasumi Osonoi
- Masaki Ryuzaki
Institutions
- Hirosaki University (JP)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1210/clinem/dgaf308
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00