Lipopolysaccharide induces retention of E-cadherin in the endoplasmic reticulum and promotes hybrid epithelial-to-mesenchymal transition of human embryonic stem cells-derived expandable lung epithelial cells
Human embryonic stem cell-derived ELEPs provide a biologically relevant, non-cancerous lung cell model to investigate molecular responses to inflammatory stimuli and address epithelial plasticity. This approach offers novel insights into the fine molecular processes underlying lung injury and repair.
Authors
- Vendula Pelková (ORCID: https://orcid.org/0000-0001-9825-9683)
- Aleš Hampl (ORCID: https://orcid.org/0000-0002-8963-9235)
- V. Havlíček (ORCID: https://orcid.org/0009-0008-8271-0001)
- Petr Vaňhara (ORCID: https://orcid.org/0000-0002-7470-177X)
- Jarmila Herůdková
- Hana Kotasová (ORCID: https://orcid.org/0000-0003-3363-2453)
- Türkan Portakal
- Tereza Gruntová
- Rıza Can Çakmakci
Institutions
- Masaryk University (CZ)
- University Hospital Brno (CZ)
Publication Details
- Journal
- Inflammation Research
- Published
- 2025-05-24
- DOI
- https://doi.org/10.1007/s00011-025-02041-4
- Citations
- 1
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- European Commission
- Grantová Agentura České Republiky
- Ministerstvo Zdravotnictví Ceské Republiky
- Central European Institute of Technology
- Masarykova Univerzita