Targeting carboxypeptidase A/B activity with the phosphinic inhibitor C28 reduces the asthmatic response in a mouse model of house dust mite-induced asthma
Compound 28 could suppress multiple features of asthma in a physiologically relevant mouse model, reinforcing the potential of targeting A/B type carboxypeptidases for therapeutic purposes in allergic asthma.
Authors
- Sara Wernersson (ORCID: https://orcid.org/0000-0003-3067-7875)
- Sowsan Taha
- David Montpeyó (ORCID: https://orcid.org/0000-0002-0327-2015)
- Srinivas Akula (ORCID: https://orcid.org/0000-0001-6628-1640)
- Laurent Devel (ORCID: https://orcid.org/0000-0002-4464-5826)
- Júlia Lorenzo (ORCID: https://orcid.org/0000-0001-5659-6008)
- Venkata Sita Rama Raju Allam (ORCID: https://orcid.org/0000-0002-4330-5299)
- Fabrice Beau
- Ida Waern (ORCID: https://orcid.org/0000-0001-6526-4339)
- Francesc Avilés (ORCID: https://orcid.org/0000-0002-1399-6789)
- Gunnar Pejler (ORCID: https://orcid.org/0000-0002-6779-391X)
Institutions
- Universitat Autònoma de Barcelona (ES)
- Uppsala University (SE)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- Swedish University of Agricultural Sciences (SE)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES)
- Maison de la Simulation (FR)
- CEA Paris-Saclay (FR)
Publication Details
- Journal
- Inflammation Research
- Published
- 2025-05-24
- DOI
- https://doi.org/10.1007/s00011-025-02046-z
- Primary Topic
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sveriges Lantbruksuniversitet