<i>Jatropha tanjorensis</i> J.L.Ellis & Saroja inhibited carbon tetrachloride-induced fibrogenesis in Wistar rats
<i>Jatropha tanjorensis</i> has been employed to treat various diseases. This study aimed to investigate the mode of action of <i>J. tanjorensis</i> against liver fibrogenesis induced by carbon tetrachloride (CCl<sub>4</sub>). Liver fibrosis was induced in male Wistar rats by exposing them to CCl<sub>4</sub> for nine weeks. From weeks 7 to 9, <i>J. tanjorensis</i> extract was administered. The study evaluated the activities of antioxidant enzymes and lipid peroxidation (LPO) levels, expression of TGFβ1 and fibrosis-associated proteins, and liver histology. <i>J. tanjorensis</i> significantly increased the depleted antioxidant activities induced by CCl<sub>4</sub> while significantly reducing the elevated LPO levels caused by CCl<sub>4</sub>. Furthermore, it downregulated the upregulation of TGFβ1 and fibrosis-associated proteins induced by CCl<sub>4</sub> and mitigated the liver lesions and collagen deposits resulting from CCl<sub>4</sub> exposure. Overall, <i>J. tanjorensis</i> alleviated liver injury and fibrogenesis by exerting its antioxidant effect and inhibition of TGFβ1.
Authors
- Enivwenaye Egide Williams Nabofa (ORCID: https://orcid.org/0000-0002-4491-2445)
- Ifeoluwa T. Oyeyemi (ORCID: https://orcid.org/0000-0002-2374-506X)
- Ifeoluwa Temitope Ajayi (ORCID: https://orcid.org/0000-0001-7326-2683)
Institutions
- University of Wolverhampton (GB)
- University College Hospital (GB)
- University College Hospital, Ibadan (NG)
- Babcock University (NG)
- University of Medical Sciences, Ondo
- University College London (GB)
- Olusegun Agagu University of Science and Technology (NG)
Publication Details
- Journal
- Natural Product Research
- Published
- 2025-05-24
- DOI
- https://doi.org/10.1080/14786419.2025.2509137
- Citations
- 1
- Primary Topic
- Curcumin's Biomedical Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.59