Acute inflammation induced by the <i>Escherichia coli</i> lipopolysaccharide considerably increases the systemic and brain exposure of olanzapine after oral administration in mice
Endotoxemia notably increases olanzapine concentrations in the plasma and brain following oral administration in mice. Further studies should clarify whether altered pharmacokinetics results in adverse effects in acutely infected patients taking oral olanzapine.
Authors
- Jolana Schreiberová
- Martin Mžik (ORCID: https://orcid.org/0000-0003-4649-7828)
- Hana Laštůvková (ORCID: https://orcid.org/0000-0002-3574-1103)
- Jan Hubeňák (ORCID: https://orcid.org/0000-0003-3080-6462)
- Stanislav Mičuda (ORCID: https://orcid.org/0000-0002-7773-7161)
- Ctirad Andrýs (ORCID: https://orcid.org/0000-0001-6489-8786)
- Jaroslav Chládek (ORCID: https://orcid.org/0000-0002-9052-6318)
- Jiří Masopust (ORCID: https://orcid.org/0009-0006-1940-5325)
- David E. Bayer
- Lenka Jandová (ORCID: https://orcid.org/0009-0006-0931-7815)
Institutions
- Charles University (CZ)
- University Hospital Hradec Králové (CZ)
- University of Hradec Králové (CZ)
Publication Details
- Journal
- The International Journal of Neuropsychopharmacology
- Published
- 2025-05-24
- DOI
- https://doi.org/10.1093/ijnp/pyaf036
- Citations
- 1
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.58
Funders
- Univerzita Hradec Králové