Đặc điểm lâm sàng và cận lâm sàng ở bệnh nhân nhược cơ có triệu chứng ở mắt

Objective: Description of clinical and paraclinical characteristics in myasthenia gravis patients with ocular symptoms at Bach Mai Hospital’s Neurological Center.Subjects and methods: Cross-sectional descriptive study of 45 myasthenia gravis patients with ocular symptoms treated at Bach Mai Hospital’s Neurological Center. Results: Females accounted for 62.22%, males 37.78%, and the mean age was 47.11 ± 14.11; 33.33% of patients had thymoma; 77.78% of patients had moderate ptosis; 64.44% of patients had age of onset < 50 years; 40% of patients have symptoms of limb weakness. Ice pack test was positive for ocular myasthenia gravis at 88%, with the generalized myasthenia gravis at 80%. Prostigmin test was positive for ocular myasthenia gravis at 92%, with the generalized myasthenia gravis at 95%.The repetitive nerve stimulation test was positive for ocular myasthenia gravis at 44%, with the generalized myasthenia gravis at 80%. Anti-acetylcholine receptor (AChR-Ab) antibody test was positive for ocular myasthenia gravis at 56%, with the generalized myasthenia gravis at 80%.Conclusion: In our study, females were more affected than males, moderate ptosis and weakness in limbs are most common. The sensitivity of Prostigmin test was highest with 92%, followed by ice pack test and RNS test, with 88% and 44%, respectively, Anti-acetylcholine receptor antibody test had a sensitivity of 56% in ocular myasthenia gravis.