A combined prospective and retrospective comparative study evaluating renal outcomes after switching from TDF + FTC + EFV to TDF/3TC/DTG (TLD) <i>vs.</i> DTG + 3TC in virologically suppressed Thai people with HIV
There was a significant reduction in eGFR among people with HIV who switched to TLD compared to those switched to DTG + 3TC. Changes in LDL and BMI were comparable between groups. Dual therapy with DTG + 3TC may be a preferred switching option over TLD for individuals with renal safety concerns. Further randomized prospective trials with longer follow-up are warranted to confirm these findings.
Authors
- Opass Putcharoen (ORCID: https://orcid.org/0000-0001-8444-8512)
- Samadhi Patamatamkul (ORCID: https://orcid.org/0000-0002-6350-9758)
- Sathaporn Kanogtorn
- Phattarapon Burimat
Institutions
- Mahasarakham University (TH)
- Thai Red Cross Society (TH)
- Chulalongkorn University (TH)
Publication Details
- Journal
- HIV Research & Clinical Practice
- Published
- 2025-05-24
- DOI
- https://doi.org/10.1080/25787489.2025.2509379
- Citations
- 1
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Mahasarakham University