Gabapentin and loperamide co-administration effect on the neuropathic pain in alloxan diabetic female albino mice

The present study aimed to evaluate the effect of gabapentin-loperamide co-administration on induced diabetic neuropathic pain in female albino mice. The study involved 30 female albino mice, divided into six groups: Group A served as the negative group and received distilled water; Group B served as the positive group (induced diabetic neuropathic pain); for 14 days, Group C included induced mice that received solely oral gabapentin (2.5 mg/kg); Group D included induced mice that received gabapentin 2.5 mg/kg for 14 days orally and loperamide 0.05 mg/kg for 14 days orally. Group E includes induced mice treated with gabapentin 1.8 mg/kg for 14 days orally and loperamide 0.05 mg/kg for 14 days orally, Group F includes induced mice treated with gabapentin 1.2 mg/kg for 14 days orally and loperamide (0.05 mg/kg) for 14 days orally. Results illustrated that Group D showed a significant decrease in the levels of substance-p and interleukin-6 (10.92 ±0.74 and 165.8 ±8.53, respectively) in comparison with those levels in Group B (108.78 ±4.46 and 1083.34 ±76.35, respectively), which may be attributed to the increase in the analgesic effect of gabapentin due to the reduction in its elimination from the body by decreasing small intestine movement and increasing absorption, which led to keeping it in the body for a long time.