Role of serum osteoprotegerin and hs-CRP levels in obese diabetic patients

Obesity is thought to be the primary environmental factors that may be contributed to the development of Type 2 diabetes mellitus (T2DM) and insulin resistance. Osteoprotegerin (OPG) has been assessed as a novel noninvasive inflammatory biomarker that directly contributes to inflammatory processes. This study aimed to elucidate the role of osteoprotegerin and high sensitivity C-reactive protein (hs-CRP) in obese diabetic patients and to explore their possible involvement in the pathogenesis of T2DM. Ninety participants divided in two group (45) T2DM obese patients compared with (45) healthy control, aged between 40-55 years. Results showed that there was a highly significant increase in the levels of hs-CRP and osteoprotegerin in obese diabetic patients compared with controls. Results also demonstrated that a positive significant correlation were exist between osteoprotegerin and body mass index, waist, systolic blood pressure, diastolic blood pressure, total cholesterol, triglyceride and low-density lipoprotein-cholesterol and a highly significant positive correlation with fasting blood sugar, hemoglobin A1c and hs-CRP, whereas negative correlation was obtained between osteoprotegerin and High-density lipoprotein cholesterol in obese diabetic patients. It was concluded that high levels of hs-CRP and OPG in obese diabetic patients and thought to be risk factors for the development of CVD which can increase the mortality rate in association with patient's incapacity to control his blood sugar levels and the imbalance in his fat contents.