Glucocorticoids <i>vs</i> glucocorticoids plus cyclophosphamide in eosinophilic granulomatosis with polyangiitis without poor-prognosis factors: a target trial emulation study
This study shows that the adjunction of CYC to GCs does not reduce the risk of relapse in patients with EGPA and no poor-prognosis factors. It supports current guidelines in patients without severe manifestations but challenges the need of CYC adjunction in patients with severe manifestations but no poor-prognosis factors.
Authors
- Claudia Feder
- Arianna Troilo (ORCID: https://orcid.org/0000-0001-7229-3058)
- Maria Letizia Urban
- Cécile‐Audrey Durel
- Nils Venhoff (ORCID: https://orcid.org/0000-0001-7729-2759)
- Bernard Bonnotte (ORCID: https://orcid.org/0000-0002-1098-4598)
- Vítor Teixeira (ORCID: https://orcid.org/0000-0002-9452-0028)
- Luc Mouthon (ORCID: https://orcid.org/0000-0002-7021-9492)
- Claus Kroegel
- Michele Iudici (ORCID: https://orcid.org/0000-0001-5871-8806)
- Maxime Samson (ORCID: https://orcid.org/0000-0002-6547-232X)
- Thomas Barba (ORCID: https://orcid.org/0000-0003-1281-0433)
- Carlomaurizio Montecucco (ORCID: https://orcid.org/0000-0001-8263-3925)
- Jens Thiel (ORCID: https://orcid.org/0000-0001-7582-1514)
- Jean‐Emmanuel Kahn (ORCID: https://orcid.org/0000-0002-9565-6074)
- Augusto Vaglio (ORCID: https://orcid.org/0000-0002-3814-9172)
- Benjamin Seeliger (ORCID: https://orcid.org/0000-0001-7373-752X)
- Chiara Marvisi (ORCID: https://orcid.org/0000-0001-7027-1410)
- Matthieu Groh (ORCID: https://orcid.org/0000-0003-0810-136X)
- Thomas Neumann (ORCID: https://orcid.org/0000-0003-3755-9038)
- Boris Sorin (ORCID: https://orcid.org/0000-0002-3443-9201)
- Xavier Puéchal (ORCID: https://orcid.org/0000-0003-3573-9203)
- Raphaël Porcher (ORCID: https://orcid.org/0000-0002-5277-4679)
- Giacomo Emmi (ORCID: https://orcid.org/0000-0001-9575-8321)
- Franco Schiavon (ORCID: https://orcid.org/0000-0002-3064-7943)
- Giulia Cassone (ORCID: https://orcid.org/0000-0002-3454-401X)
- David R.W. Jayne (ORCID: https://orcid.org/0000-0002-1712-0637)
- Francesco Locatelli (ORCID: https://orcid.org/0009-0001-1630-7950)
- Renato Alberto Sinico (ORCID: https://orcid.org/0000-0002-9470-218X)
- Juliane Mahrhold
- Sara M. Monti (ORCID: https://orcid.org/0000-0002-1800-6772)
- Bernhard Hellmich (ORCID: https://orcid.org/0000-0002-8014-1801)
- Benjamin Terrier (ORCID: https://orcid.org/0000-0001-6612-7336)
- Carlo Salvarani (ORCID: https://orcid.org/0000-0003-3708-3148)
- Loïc Guillevin
- Matthias Papo
Institutions
- University of Modena and Reggio Emilia (IT)
- University of Padua (IT)
- Université de Versailles Saint-Quentin-en-Yvelines (FR)
- Université Paris Cité (FR)
- University of Cambridge (GB)
- University of Pavia (IT)
- Dialog Semiconductor (Germany) (DE)
- Kantonsspital St. Gallen (CH)
- University Medical Center Freiburg (DE)
- Hotel Dieu Hospital (CA)
- Medizinische Hochschule Hannover (DE)
- Azienda Sanitaria Unità Locale di Reggio Emilia (IT)
- Hôpital Cochin (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Meyer Children's Hospital (IL)
- University Hospital of Geneva (CH)
- Administração Regional de Saúde de Lisboa e Vale do Tejo (PT)
- Meyer Children's Hospital (IT)
- Université Bourgogne Franche-Comté (FR)
- Algarve Biomedical Center (PT)
- Hôpital Edouard Herriot (FR)
- Hôtel-Dieu de Paris (FR)
- Jena University Hospital (DE)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Hôpital Foch (FR)
- IRCCS Humanitas Research Hospital (IT)
- University of Florence (IT)
- Geneva College (US)
- University of Algarve (PT)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2025-05-24
- DOI
- https://doi.org/10.1093/rheumatology/keaf256
- Citations
- 2
- Primary Topic
- Eosinophilic Disorders and Syndromes
- Type
- article
- Field-Weighted Citation Impact
- 3.34