JNK1 in SF1 neurons regulates the central action of thyroid hormones on hepatic lipid metabolism
Our data demonstrated for the first time that JNK1 in SF1 neurons is necessary for the regulation of hepatic lipid metabolism, cold adaptation and central T3 actions.
Authors
- Eva Rial‐Pensado (ORCID: https://orcid.org/0000-0002-2645-6626)
- José L. Labandeira‐García (ORCID: https://orcid.org/0000-0002-8243-9791)
- Angela Martinez Valverde (ORCID: https://orcid.org/0000-0003-1192-9045)
- Vítor Ferreira (ORCID: https://orcid.org/0000-0002-0107-9510)
- Ismael González‐García (ORCID: https://orcid.org/0000-0002-5545-5841)
- Roger J. Davis (ORCID: https://orcid.org/0000-0002-0130-1652)
- Carlos Diéguez (ORCID: https://orcid.org/0000-0002-0919-4337)
- Pablo Garrido‐Gil (ORCID: https://orcid.org/0000-0001-7734-8783)
- Guadalupe Sabio (ORCID: https://orcid.org/0000-0002-2822-0625)
- Olga Barca‐Mayo (ORCID: https://orcid.org/0000-0002-2335-7980)
- Patricia Rada (ORCID: https://orcid.org/0000-0002-6731-2098)
- Jens Mittag (ORCID: https://orcid.org/0000-0001-7778-5158)
- Iara Fernández-González
- Óscar Freire-Agulleiro (ORCID: https://orcid.org/0000-0001-9843-2650)
- María Silveira-Loureiro (ORCID: https://orcid.org/0000-0002-9079-3563)
- Miguel López (ORCID: https://orcid.org/0000-0002-7823-1648)
- Rubén Nogueiras
- Gloria Martı́nez
Institutions
- University of Massachusetts Chan Medical School (US)
- Universidade de Santiago de Compostela (ES)
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (ES)
- Centro Nacional de Epidemiología (ES)
- Centro Nacional de Biotecnología (ES)
- Center for Research in Molecular Medicine and Chronic Diseases (ES)
- Spanish National Centre for Cardiovascular Research (ES)
- Instituto de Investigación Sanitaria de Santiago (ES)
- Universidad Autónoma de Madrid (ES)
- University of Lübeck (DE)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-05-24
- DOI
- https://doi.org/10.1016/j.molmet.2025.102170
- Citations
- 3
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Fundación Científica Asociación Española Contra el Cáncer
- Ministerio de Ciencia e Innovación
- Xunta de Galicia
- European Research Council
- European Regional Development Fund
- FP7 Ideas: European Research Council