Toxoplasma TgCtwh3 Δrop16 accelerates neuronal apoptosis and APP production in mouse with acute infection
Our results indicated that the GRA15<sub>Ⅱ</sub> effector may play a crucial part in neuron apoptosis, pro-inflammatory factors secretion, and APP, BACE1 production. Inversely, ROP16<sub>Ⅰ/Ⅲ</sub> effector may play a potentially protective role in this process.
Authors
- Kunpeng Qin
- Qing Tao (ORCID: https://orcid.org/0000-0002-0929-1225)
- Jilong Shen (ORCID: https://orcid.org/0000-0002-4755-3687)
- Li Yu
- Jian Du (ORCID: https://orcid.org/0000-0001-5010-7859)
- Deyong Chu
- Mengmeng Jin (ORCID: https://orcid.org/0000-0002-2749-8000)
- Lei Liu (ORCID: https://orcid.org/0000-0002-4966-5914)
- Haiping Cai (ORCID: https://orcid.org/0000-0002-0094-3119)
- Meijuan Zheng (ORCID: https://orcid.org/0000-0002-7378-3355)
- Cong Wang (ORCID: https://orcid.org/0000-0002-0728-2843)
- Qingli Luo (ORCID: https://orcid.org/0000-0001-6173-353X)
- Mengtao Gong
- Di Yang (ORCID: https://orcid.org/0009-0008-0779-2692)
Institutions
- University of Science and Technology of China (CN)
- Anhui Medical University (CN)
- Nanjing Drum Tower Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- IBRO Neuroscience Reports
- Published
- 2025-05-24
- DOI
- https://doi.org/10.1016/j.ibneur.2025.05.009
- Primary Topic
- Toxoplasma gondii Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Anhui Medical University