The Effect of Exogenous Ketones on Signs and Symptoms of Schizophrenia Spectrum and Bipolar Disorders: Study Protocol for a Triple-Blind, Randomized, Controlled Crossover Pilot Study
Our current study will offer valuable preliminary data on the effects of KE in patients with SSD and BD. It can provide the foundation for future research into the therapeutic potential of KE in alleviating symptoms and improving functional outcomes in these disorders.This trial was registered at www.clinicaltrials.gov as NCT06426134.
Authors
- Tim Ziermans (ORCID: https://orcid.org/0000-0001-5224-1365)
- Astrid M. Kamperman (ORCID: https://orcid.org/0000-0003-4455-6492)
- Ralph Kupka (ORCID: https://orcid.org/0000-0002-1662-7436)
- Maarten R. Soeters (ORCID: https://orcid.org/0000-0001-5008-6752)
- Dirk JA. Smit
- Eline Dekeyster
- Lieuwe de Haan (ORCID: https://orcid.org/0000-0002-3820-7926)
- Marieke van der Pluijm (ORCID: https://orcid.org/0000-0003-0665-7911)
- Karin Huizer (ORCID: https://orcid.org/0000-0002-0932-8139)
- Yagmur Yurtkap
- Sriram Muthukumar (ORCID: https://orcid.org/0000-0002-8761-7278)
- Mirjam J. van Tricht
- Bob Oranje (ORCID: https://orcid.org/0000-0001-8408-4800)
- Shalini Prasad (ORCID: https://orcid.org/0000-0002-2404-3801)
- Bram‐Sieben Rosema
- Rocco Hoekstra (ORCID: https://orcid.org/0000-0001-8122-6703)
- Jason R.B. Dyck (ORCID: https://orcid.org/0000-0002-7045-2884)
- Nico JM van Beveren
- Daphne A M Dielemans
- Romée L van der Mieden van Opmeer
Institutions
- Leiden University (NL)
- University Medical Center Groningen (NL)
- University of Alberta (CA)
- The University of Texas at Dallas (US)
- University of Applied Sciences Leiden (NL)
- Erasmus MC (NL)
- Glostrup Hospital (DK)
- Allen Hospital (US)
- Parnassia Groep (NL)
- GGz centraal (NL)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Current Developments in Nutrition
- Published
- 2025-05-24
- DOI
- https://doi.org/10.1016/j.cdnut.2025.107480
- Citations
- 2
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- Amsterdam University Medical Centers
- Amsterdam Neuroscience