Type II fibre atrophy and nuclear disruption in decompensated cirrhosis
Our study illustrates the presence of myopathy at the histological level in patients with cirrhosis undergoing liver transplantation. Patients with decompensated cirrhosis, compared with compensated cirrhosis, exhibit type II (glycolytic) muscle fibre atrophy and disruption of nuclear positioning. Patients with decompensated cirrhosis gain an extended survival benefit from liver transplantation but are likely to begin this extension of life enfeebled by loss of muscle mass and function. The involvement of glycolytic muscle fibres may have implications for strength and fatiguability; thus, post-transplant resistance exercise may help with rehabilitation.
Authors
- Aldo J. Montaño‐Loza (ORCID: https://orcid.org/0000-0002-2511-7980)
- Vickie E. Baracos (ORCID: https://orcid.org/0000-0002-9609-1001)
- Maryam Motamedrad
- Khaled Dajani (ORCID: https://orcid.org/0000-0002-8507-1160)
- Abha R. Dunichand‐Hoedl
- David L. Bigam (ORCID: https://orcid.org/0000-0003-2285-4173)
- A. M. James Shapiro (ORCID: https://orcid.org/0000-0002-6215-0990)
- Elora Rider
- Alessandro Parente (ORCID: https://orcid.org/0000-0001-5506-224X)
- Blaire Anderson (ORCID: https://orcid.org/0000-0003-4740-3192)
- Norman M. Kneteman (ORCID: https://orcid.org/0000-0001-7610-6053)
- Vera C. Mazurak (ORCID: https://orcid.org/0000-0002-7724-6354)
- Norberto Sánchez-Fernández
- Maryam Ebadi
Institutions
- University of Alberta (CA)
- Alberta Hospital Edmonton (CA)
- University of Alberta Hospital (CA)
- King's College Hospital (GB)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-05-24
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101455
- Citations
- 1
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 1.32
Funders
- Canadian Association for the Study of the Liver
- University of Alberta
- Canadian Liver Foundation
- Canadian Institutes of Health Research
- Institute of Nutrition, Metabolism and Diabetes