Magnetizable flow diverters can magnetically capture and retain endothelial cells to promote healing in rabbit arteries

Flow diverters are effective endovascular devices used to treat intracranial aneurysms by facilitating aneurysm occlusion through endothelial growth across the aneurysm neck. Rapid endothelialization reduces complications such as thrombosis and stenosis. This technical note describes braided, magnetizable flow diverters made from stainless steel alloy 2205 (SS2205) wires designed to magnetically capture autologous blood outgrowth endothelial cells (BOECs) labeled with superparamagnetic iron oxide nanoparticles (SPIONs). Preclinical rabbit artery deployments demonstrated successful magnetic capture and retention of SPION-labeled BOECs, indicating feasibility for accelerated endothelialization. Detailed technical specifications provided in this manuscript ensure precise reproducibility, aiding future studies exploring advanced endothelialization strategies in neuroradiology.