HMGB1 Inhibition Alleviates Chronic Nonbacterial Prostatitis by Suppressing M1 Polarization of Macrophages
HMGB1 can enhance TRAF6-mediated NF-κB activation, thereby driving M1 macrophage polarization and exacerbating prostate inflammation in EAP mice. Inhibiting HMGB1 expression with glycyrrhizin can suppress M1 polarization of macrophages to alleviate prostate inflammation. This study suggests that targeting the HMGB1/TRAF6/NF-κB signaling pathway may be an effective therapeutic approach for CP/CPPS.
Authors
- Ping Jiang (ORCID: https://orcid.org/0000-0002-7890-6713)
- Jiaxin Zhou (ORCID: https://orcid.org/0000-0002-1664-3495)
- Qing Jiang (ORCID: https://orcid.org/0000-0003-1015-9886)
- Liang‐Wen Ding (ORCID: https://orcid.org/0009-0002-7808-8826)
- Z. Mei
- Xiaoliang Hua (ORCID: https://orcid.org/0000-0001-5095-8872)
- Juan Chen (ORCID: https://orcid.org/0000-0001-6920-7972)
- Chen Chen (ORCID: https://orcid.org/0009-0003-6443-5732)
Institutions
- Dalian Medical University (CN)
- Wuhan University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-05-01
- DOI
- https://doi.org/10.2147/jir.s502616
- Citations
- 1
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 1.32
Funders
- Natural Science Foundation of Chongqing
- Centre Scientifique et Technique du Bâtiment