Stomatobaculum longum-Derived Extracellular Vesicles Enhance Oral Squamous Cell Carcinoma Malignancy Through BRCA1/EXO1/TP53BP1 Modulation
This study demonstrates the oncogenic role of <i>S. longum</i> in OSCC, mediated through EVs-dependent regulation of the BRCA1/EXO1/TP53BP1 pathway. Targeting bacterial EVs or their downstream signaling may represent a novel therapeutic strategy for OSCC.
Authors
- Yachong Li (ORCID: https://orcid.org/0009-0005-2558-8263)
- Zeman Qin (ORCID: https://orcid.org/0000-0002-4406-0406)
- Lingjian Yan
- Fan Wu (ORCID: https://orcid.org/0000-0002-1261-1410)
- Jiuyang Jiao
- Qingchun Liang (ORCID: https://orcid.org/0000-0003-4786-9304)
- Libin Shao
- Xinxin Xiong (ORCID: https://orcid.org/0000-0002-1660-6352)
- Abudusaimi Maimaiti
Institutions
- Sun Yat-sen University (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- People's Hospital of Xinjiang Uygur Autonomous Region (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-05-01
- DOI
- https://doi.org/10.2147/ijn.s491473
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81