IntelliCircos: A Data‐driven and AI‐powered Authoring Tool for Circos Plots

Abstract Genomics data is essential in biological and medical domains, and bioinformatics analysts often manually create circos plots to analyze the data and extract valuable insights. However, creating circos plots is complex, as it requires careful design for multiple track attributes and positional relationships between them. Typically, analysts often seek inspiration from existing circos plots, and they have to iteratively adjust and refine the plot to achieve a satisfactory final design, making the process both tedious and time‐intensive. To address these challenges, we propose IntelliCircos, an AI‐powered interactive authoring tool that streamlines the process from initial visual design to the final implementation of circos plots. Specifically, we build a new dataset containing 4396 circos plots with corresponding annotations and configurations, which are extracted and labeled from published papers. With the dataset, we further identify track combination patterns, and utilize Large Language Model (LLM) to provide domain‐specific design recommendations and configuration references to navigate the design of circos plots. We conduct a user study with 8 bioinformatics analysts to evaluate IntelliCircos, and the results demonstrate its usability and effectiveness in authoring circos plots.