Clinical, immune cell, and genetic features predicting survival and long-term response to first-line chemo-immunotherapy treatment for non-small cell lung cancer
This study provides some new insights into the features and predictors significantly associated with LTR and survival in NSCLC patient receiving first-line treatment of anti-PD-1 plus chemotherapy. Those whose age < 65 years, overweight or obesity, or has a baseline CAR score < 0.07 are more likely to achieve optimal benefit from the first-line treatment of chemo-immunotherapy.
Authors
- Xiaohong Han (ORCID: https://orcid.org/0000-0001-9190-0167)
- Haohua Zhu (ORCID: https://orcid.org/0000-0002-7914-0289)
- Zucheng Xie (ORCID: https://orcid.org/0000-0002-7910-9660)
- Le Tang (ORCID: https://orcid.org/0000-0002-5192-3329)
- Xingsheng Hu (ORCID: https://orcid.org/0000-0002-6652-2384)
- Yu Feng (ORCID: https://orcid.org/0000-0001-5507-1883)
- Liling Huang (ORCID: https://orcid.org/0000-0002-5023-8370)
- Jiarui Yao (ORCID: https://orcid.org/0000-0002-9835-395X)
- Lin Lin (ORCID: https://orcid.org/0000-0001-6374-2165)
- Hongyu Wang (ORCID: https://orcid.org/0000-0002-4556-9546)
- Yutao Liu (ORCID: https://orcid.org/0000-0001-6477-9875)
- Xuezhi Hao (ORCID: https://orcid.org/0000-0002-2846-2501)
- Yuankai Shi (ORCID: https://orcid.org/0000-0002-3342-4964)
- Xinrui Chen (ORCID: https://orcid.org/0000-0001-8780-4076)
- Liyuan Dai (ORCID: https://orcid.org/0009-0007-4848-3709)
- Shengyu Zhou (ORCID: https://orcid.org/0000-0002-6254-2986)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-05-24
- DOI
- https://doi.org/10.1007/s00262-025-04022-2
- Citations
- 2
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Chinese Academy of Medical Sciences