LncRNA16 inhibits pyroptosis and promotes platinum resistance in non-small cell lung cancer by sponging miRNA1827 to regulate MBD3/GSDME expression
We identified a novel function of lncRNA16 in inhibiting pyroptosis and proposed an effective therapeutic drug, the miRNA1827 agomir, for chemosensitization. This study offers a potential strategy for treating patients with NSCLC, especially those with platinum resistance.
Authors
- Kuiyu Gong
- Jiangyan Chen
- Yuanjun Zeng (ORCID: https://orcid.org/0000-0002-2283-4546)
- Zhiqiang Wang (ORCID: https://orcid.org/0000-0001-8993-1917)
- Guihua Wang (ORCID: https://orcid.org/0000-0001-5423-9357)
- Yanfang Liu (ORCID: https://orcid.org/0000-0002-4091-7679)
- Yang Zhao (ORCID: https://orcid.org/0000-0003-1444-5927)
- Sikai Wang
Institutions
- Central South University (CN)
- Changsha Medical University (CN)
- Hunan Normal University (CN)
- Hunan Provincial People's Hospital (CN)
- Shanxi Datong University (CN)
- University of South China (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-05-24
- DOI
- https://doi.org/10.1186/s12935-025-03812-z
- Citations
- 2
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Education Department of Hunan Province