Network pharmacology and experimental validation to elucidate the mechanism of the treatment of polycystic ovary syndrome with insulin resistance by Resina Draconis
RD might improve insulin resistance and ovarian function in PCOS-IR by upregulating PI3K, p-PI3K, Akt, p-Akt and GLUT4 expression and downregulating FOXO3a and P27, thereby activating the PI3K/Akt signaling pathway. RD also regulated the LH/FSH ratio, increased E2 levels, reduced LH and T levels, and alleviated PCOS-IR symptoms in a rat PCOS-IR model.
Authors
- Xiusong Tang
- Jianhui Gu (ORCID: https://orcid.org/0000-0001-7181-9409)
- Jun Luo (ORCID: https://orcid.org/0000-0001-8974-015X)
- Yehao Luo
- Yueting Liu
- Ting Lv (ORCID: https://orcid.org/0000-0002-0097-9621)
- Gang Fang (ORCID: https://orcid.org/0000-0001-9847-114X)
- Jing Wang (ORCID: https://orcid.org/0009-0009-3512-2124)
- Zheng Huang (ORCID: https://orcid.org/0000-0001-5590-3328)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Guangxi University (CN)
- Guangxi University of Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Ovarian Research
- Published
- 2025-05-24
- DOI
- https://doi.org/10.1186/s13048-025-01685-4
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Guangxi University