Dehydrodiisoeugenol alleviates palmitate-induced mitochondrial dysfunction in human vascular smooth muscle cells through the activation of SIRT1-mediated Drp1 deacetylation
Deh was able to inhibit Drp1 expression and mitochondrial ectopia by reducing Drp1 acetylation through activation of SIRT1, thereby inhibiting PA-induced mitochondrial dysfunction effects in VSMCs, ameliorating pathological processes, such as cellular oxidative stress and apoptosis, and maintaining stable cellular functions.
Authors
- Mengze Sun (ORCID: https://orcid.org/0000-0002-8798-4326)
- W. M. Song (ORCID: https://orcid.org/0000-0003-1376-2293)
- Jianjun Zhao (ORCID: https://orcid.org/0000-0003-3008-3655)
- Shaomin Shi (ORCID: https://orcid.org/0000-0003-3096-1075)
- Wenqing Zhang (ORCID: https://orcid.org/0000-0002-2551-6375)
- Hongyuan Cheng
- Xiangjun Li (ORCID: https://orcid.org/0000-0003-4901-6065)
- Zhiyun Shu (ORCID: https://orcid.org/0009-0005-0285-2818)
Institutions
- Union Hospital (HK)
- Jilin University (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2025-05-24
- DOI
- https://doi.org/10.1186/s12944-025-02611-9
- Citations
- 1
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 1.22