Pharmacokinetic/Pharmacodynamic Modelling and Monte Carlo Simulations to Predict Cytomegalovirus Viral Load in Pediatric Transplant Recipients Treated with (val)Ganciclovir
The pharmacodynamic model accurately predicted observed data. Simulations indicated that maintaining a ganciclovir plasma AUC<sub>0-24</sub> around 40-60 mg·h/L maximized antiviral efficacy. An AUC<sub>0-24</sub> > 60 mg·h/L might increase the risk of adverse events without providing additional efficacy.
Authors
- Sylvain Bénito
- Jean‐Baptiste Woillard (ORCID: https://orcid.org/0000-0003-1695-0695)
- Philippe Ovetchkine
- Julie Autmizguine (ORCID: https://orcid.org/0000-0001-8975-5052)
- Annabelle Briand
- Yves Théorêt (ORCID: https://orcid.org/0000-0002-2353-860X)
- Bénédicte Franck (ORCID: https://orcid.org/0000-0001-8150-3467)
- Kévin Koloskoff
- Julien Welzel
Institutions
- Inserm (FR)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- Institut de Recherche en Santé, Environnement et Travail (FR)
- CIC Rennes (FR)
- Clinique Victor Hugo (FR)
- Pharmacologie & Transplantation (FR)
- Université de Limoges (FR)
- Université de Montréal (CA)
Publication Details
- Journal
- Clinical Pharmacokinetics
- Published
- 2025-05-24
- DOI
- https://doi.org/10.1007/s40262-025-01526-z
- Citations
- 1
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Agence Nationale de la Recherche
- Association Nationale de la Recherche et de la Technologie
- Université de Limoges