In-vitro Comparative Quality Evaluation of Alverine citrate 60mg Tablets Available in Bangladesh

In developing countries, the use of generic medicine as a cost-saving measure in health care provision has been increasing daily. Alverine citrate (ALV), a smooth muscle relaxant, is Available in the form of Tablets from different pharmaceutical companies in the local market of Bangladesh. So, the quality control test is needed to check the pharmaceutical similarity through which one product might securely substitute another. Therefore, we designed this project to appraise the ALV 60mg Tablets’ excellence Available from various manufacturers in Bangladesh. Tablet form of ALV 60mg generic from 4 different manufacturers were assessed for quality control. All the studied variables, namely, weight variation, disintegration, friability, dissolution, and hardness tests were done based on USP and BP guidelines. Tests were performed in triplicates, and the mean value was considered for expressing results. The result revealed that weight variation ranged from 202.5mg to 314.5mg. In the hardness study, the maximum and minimum values found were 4.6kg/cm2 and 2.6kg/cm2, respectively. In contrast, the highest value of friability was 0.19%. In the disintegration test, all the products disintegrated fully within 186 sec. Whereas the dissolution study showed that all the tested ALV Tablets released 97.2% of the drug within 15 minutes. Finally, it can be assured that the studied brands presented unique quality within the pharmacopeial limit. Nevertheless, further in-vivo analysis would be desired to confirm their pharmacological equivalence.