The Effect of Administration of Parijoto Fruit Extract Gel (Medinilla speciosa) on Incision Wound Healing and Total Leukocyte Count in Male Wistar White Rats

Wounds are injuries to the skin's anatomical structure and function, frequently encountered in daily life. Parijoto fruit (Medinilla speciosa) is recognized for its pharmacological activity and high flavonoid content, suggesting its potential in accelerating wound healing when topically applied. This study aimed to assess the efficacy of Parijoto fruit formulated in gel for wound healing and leukocyte count determination. Experimental laboratory research employed white male rats (Wistar) as test subjects, with Parijoto fruit metabolites extracted using the maceration method and ethanol solvent. Treatments included six groups: Octenilin gel positive control, negative control (untreated), gel base control, and extract gel treatment groups at concentrations of 0.5%, 1%, and 1.5%. Observations over 14 days focused on wound closure and leukocyte count. Results indicated that the 1.5% concentration of Parijoto fruit extract gel exhibited comparable efficacy to the positive control in terms of wound closure and anti-inflammatory activity. Moreover, administering Parijoto fruit extract gel at varying concentrations reduced leukocyte counts. Rats treated with Parijoto fruit ethanol extract gel demonstrated initial wound closure by day two, reaching complete closure by day 13, suggesting its potential as a wound-healing agent.