Transcriptional regulation of tumor suppressor gene RASSF1A by HBx
These findings suggest HBx enhances RASSF1A promoter activity and upregulates transcription via SP1, potentially preceding RASSF1A promoter methylation. This study provides new insights into HBx's regulation of the tumor suppressor gene RASSF1A in HBV-related liver cancer.
Authors
- Yi Kang (ORCID: https://orcid.org/0000-0002-4282-1013)
- Lin Yang (ORCID: https://orcid.org/0000-0001-8746-9255)
- Wei Li (ORCID: https://orcid.org/0000-0002-7267-6494)
- Junfeng Wei
- Yanhong Kang
Institutions
- Sun Yat-sen University (CN)
- Henan Provincial People's Hospital (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Molecular and Cellular Probes
- Published
- 2025-05-24
- DOI
- https://doi.org/10.1016/j.mcp.2025.102034
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00