Activated melanocytes and senescent collagen fibers predict laser-treated melasma outcomes: An optical biopsy–based prospective cohort study
Optical biopsy using CRFF-OCT revealed that patterns of activated melanocytes and senescent collagen fibers can serve as predictive markers for post-laser treatment outcomes. The photoaging characteristics of melasma were improved through the reduction of activated melanocytes and the repair of the BM.
Authors
- Yen‐Jen Wang (ORCID: https://orcid.org/0000-0002-0425-9154)
- Jia‐Wei Shen (ORCID: https://orcid.org/0000-0002-2568-4512)
- Meng‐En Lu (ORCID: https://orcid.org/0000-0002-2803-147X)
- Hsiu‐Mei Chiang (ORCID: https://orcid.org/0000-0002-1586-910X)
- Bor‐Shyh Lin (ORCID: https://orcid.org/0000-0002-8653-2571)
- Chang‐Cheng Chang (ORCID: https://orcid.org/0000-0002-0463-7346)
- Yu‐Hung Wu (ORCID: https://orcid.org/0000-0001-5579-2197)
- Ling Huang (ORCID: https://orcid.org/0000-0001-8254-2548)
- Yu‐Chang Shih (ORCID: https://orcid.org/0009-0009-5801-1347)
- I‐Ling Chen (ORCID: https://orcid.org/0000-0003-1270-4198)
- Hsin‐Mei Cheng
Institutions
- National Yang Ming Chiao Tung University (TW)
- China Medical University (TW)
- Mackay Memorial Hospital (TW)
- Apollo Institute of Medical Sciences & Research (IN)
- China Medical University Hospital (TW)
- Mackay Junior College of Medicine, Nursing and Management (TW)
Publication Details
- Journal
- Photodiagnosis and Photodynamic Therapy
- Published
- 2025-05-24
- DOI
- https://doi.org/10.1016/j.pdpdt.2025.104648
- Citations
- 2
- Primary Topic
- Dermatologic Treatments and Research
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- Ministry of Science and Technology of the People's Republic of China
- China Medical University