Distribution of CCR5-Delta32, CCR2-64I, and SDF1-3’A host genetic factors in HIV-infected and uninfected individuals in Luanda, Angola
We found no CCR5-Delta32 allele, while CCR2-64I and SDF1-3'A were found and presented a relationship with HIV infection, age, ABO/RH blood group, and HIV-1 subtypes. The observed associations of CCR2-64I and SDF1-3'A with HIV underscore the urgent need for further multidisciplinary research, with potential implications for targeted prevention and public health strategies. Therefore, studies investigating biological and non-biological factors related to susceptibility to HIV infection and AIDS progression or death should be conducted in Angola.
Authors
- Edson Kuatelela Cassinela (ORCID: https://orcid.org/0000-0002-1953-813X)
- Joana Sebastião (ORCID: https://orcid.org/0009-0005-4287-6902)
- Jocelyne Neto de Vasconcelos (ORCID: https://orcid.org/0000-0002-7318-693X)
- Euclides Nenga Manuel Sacomboio (ORCID: https://orcid.org/0000-0002-2341-9133)
- Domingos Jandondo (ORCID: https://orcid.org/0000-0001-6943-7890)
- Cruz S. Sebastião (ORCID: https://orcid.org/0000-0003-1232-0119)
- Joana Morais (ORCID: https://orcid.org/0000-0002-4524-4055)
- Miguel Brito (ORCID: https://orcid.org/0000-0001-6394-658X)
- Victor Pimentel (ORCID: https://orcid.org/0000-0001-6390-4128)
- Ana Abecasis (ORCID: https://orcid.org/0000-0002-3903-5265)
- Marta Pingarilho (ORCID: https://orcid.org/0000-0002-7928-3087)
Institutions
- Universidade Politécnica de Lisboa (PT)
- Agostinho Neto University (AO)
- Instituto de Medicina Tropical (PY)
- Escola Nacional de Saúde Pública (BR)
- Instituto Superior de Ciencias Sociais e Relações Internacionais (AO)
- Universidade Nova de Lisboa (PT)
Publication Details
- Journal
- AIDS Research and Therapy
- Published
- 2025-05-24
- DOI
- https://doi.org/10.1186/s12981-025-00751-7
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação Calouste Gulbenkian
- Centro Nacional de Investigaciones Cardiovasculares
- Fundação para a Ciência e a Tecnologia