A direct, real-time, size-resolved analytical strategy to follow drug loading and release from biocompatible gold nanoparticles
The tailored strategy employed in our investigation provided detailed, real-time, in situ analysis, making it a powerful tool for designing and optimizing drug delivery systems, providing insight into both loading and release mechanisms, assessing nanoparticle stability, and tolerating saline media. These results suggest that AF4-DAD-MALS is a more reliable and insightful technique for studying the stability, loading efficiency, and release dynamics of nanoparticle-based drug delivery systems.
Authors
- Anna Placci (ORCID: https://orcid.org/0009-0005-3332-6909)
- Barbara Roda (ORCID: https://orcid.org/0000-0003-1060-2921)
- Valentina Marassi (ORCID: https://orcid.org/0000-0001-8742-3708)
- Andrea Zattoni (ORCID: https://orcid.org/0000-0001-6971-5360)
- Junjie Wang (ORCID: https://orcid.org/0000-0002-2736-1522)
- Pierluigi Reschiglian (ORCID: https://orcid.org/0000-0003-0332-7650)
- Stefano Giordani (ORCID: https://orcid.org/0009-0005-6357-3679)
Institutions
- Istituto Nazionale Biostrutture e Biosistemi (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Analytica Chimica Acta
- Published
- 2025-05-24
- DOI
- https://doi.org/10.1016/j.aca.2025.344246
- Citations
- 3
- Primary Topic
- Nanoparticle-Based Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 1.79
Funders
- China Scholarship Council