Efficient delivery of small RNAs to podocytes in vitro by direct exosome transfection
These findings demonstrate that direct exosome transfection with fluorescently-labeled small RNAs is an effective method for tracking exosomal cargo in podocytes. This study is the first to show that directly transfected exosomes can deliver small RNAs to podocytes in vitro, suggesting their potential as RNA carriers for therapeutic strategies in more complex settings.
Authors
- Doreen Biedenweg (ORCID: https://orcid.org/0000-0002-4175-2618)
- Lea Maron (ORCID: https://orcid.org/0000-0002-4931-0013)
- Rabea Schlüter
- Claudia Weber (ORCID: https://orcid.org/0000-0002-5910-8898)
- Tim Lange (ORCID: https://orcid.org/0000-0002-0716-7845)
- Nicole Endlich (ORCID: https://orcid.org/0000-0001-6817-4099)
Institutions
- Universitätsmedizin Greifswald (DE)
- Universität Greifswald (DE)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-05-23
- DOI
- https://doi.org/10.1186/s12951-025-03426-7
- Citations
- 5
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- Bundesministerium für Bildung und Forschung